Highway 97 just south of Redmond was partially closed Friday around 2 p.m. after a crash involving two vehicles.
Redmond Fire & Rescue said two people were removed from the cars and taken to St. Charles in Bend.
One patient sustained life-threatening injuries.
Captain Bill Welch said when firefighters and paramedics arrived they found the vehicles with extensive damage.
The highway reopened around 4:30.
Road and weather conditions slowed response times.
Bend Fire & Rescue, Oregon State Police, Deschutes County Sheriff’s Office and the Oregon Department of Transportation assisted Redmond Fire & Rescue at the scene.